Table 2.
Uni- and multivariable logistic regression analyses for gastrointestinal bleeding in patients with HHT.
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p | OR | 95% CI | p | |
| Male | 1.64 | 0.66–4.08 | 0.283 | 0.90 | 0.15–5.32 | 0.910 |
| Age, years | 1.02 | 0.98–1.05 | 0.339 | 1.07 | 1.06–1.14 | 0.033 |
| Age > 50 years | 2.30 | 0.86–6.16 | 0.095 | 2.06 | 0.07–61.42 | 0.676 |
| Smoking | 3.27 | 1.26–8.48 | 0.015 | 7.82 | 1.37–44.52 | 0.020 |
| ENG mutations | 4.42 | 1.25–15.57 | 0.021 | 5.72 | 1.02–31.93 | 0.047 |
| ACVRL1 mutations | 0.31 | 0.10–0.99 | 0.049 | 1.99 | 0.07–54.84 | 0.685 |
| Ferritin levels < 15 ug/L | 4.07 | 1.5–11.03 | 0.006 | 3.09 | 0.55–17.5 | 0.202 |
| Hemoglobin, g/dL | 0.97 | 0.95–0.99 | 0.003 | 0.96 | 0.93–0.96 | 0.033 |
| Hemoglobin levels < 8 g/dL | 2.18 | 0.83–5.76 | 0.112 | 0.75 | 0.09–6.55 | 0.801 |
| ESS ≥ 4 | 2.20 | 0.87–5.57 | 0.095 | 1.57 | 0.26–9.66 | 0.624 |
OR: odds ratio; 95% CI: 95% confidence intervals; ACVRL1: activin A receptor type II-like 1 gene; ENG: endoglin gene; ESS: epistaxis severity score.