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. 2020 Jan 20;9(1):281. doi: 10.3390/jcm9010281

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Diagnostic significance of serum alpha-fetoprotein (AFP), serum exo-miR-10b-5p, and miR-215-5p in diagnosing HCC in the validation cohort comprising 28 normal individuals, 27 patients with chronic hepatitis B, 33 patients with liver cirrhosis, and 90 patients with HCC. (a) Comparison of serum AFP level and expression of two serum exo-miRs based on stage of liver disease. (b) AUC of serum AFP and two serum exo-miRs in diagnosing HCC. (c) AUC of serum AFP and two serum exo-miRs in diagnosing mUICC stage I or II HCC. (d) AUC of serum AFP and two serum exo-miRs in diagnosing mUICC stage I HCC.