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. 2020 Jan 15;9(1):226. doi: 10.3390/jcm9010226

Figure 9.

Figure 9

A schematic pathway for MVS-induced HO-1 expression in HPAEpiCs. MVS attenuated TNF-α-induced ICAM-1 expression and lung monocyte/leukocyte accumulation through upregulation of HO-1 via enhanced p47phox/Nox2 activity, resulting in the accumulation of intracellular ROS. Imbalance in oxidative stress promoted the phosphorylation of c-Src/PDGFRα/PI3K/Akt and then activation of Nrf2. Nuclear translocation of Nrf2 bound to the ARE region of the HO-1 promoter and increased the HO-1 gene expression in HPAEpiCs.