Table 1.
Baseline characteristics between CRC patients and healthy control subjects.
| Characteristic | Control (n = 416) | CRC (n = 474) | P* | Colon (n = 272) | P* | Rectum (n = 189) | P* |
|---|---|---|---|---|---|---|---|
| Male, n (%) | 173 (41.6) | 214 (45.1) | 0.317 | 122 (44.9) | 0.443 | 84 (44.4) | 0.568 |
| Age (mean ± SD) | 61.2 ± 11.38 | 62.1 ± 12.48 | 0.230 | 61.9 ± 12.97 | 0.267 | 62.1 ± 11.81 | 0.344 |
| HTN, n (%) | 168 (40.4) | 157 (33.1) | 0.030 | 86 (31.6) | 0.025 | 68 (36) | 0.347 |
| DM, n (%) | 55 (13.2) | 76 (16.0) | 0.277 | 46 (16.9) | 0.220 | 30 (15.9) | <0.0001 |
| Folate (mean ± SD) | 9.0 ± 8.05 | 7.8 ± 6.82 | <0.0001 | 7.9 ± 6.77 | <0.0001 | 7.7 ± 6.97 | <0.0001 |
| Hcy (mean ± SD) | 9.8 ± 4.25 | 10.7 ± 7.8 | 0.330 | 10.4 ± 8.12 | 0.870 | 10.9 ± 7.34 | 0.096 |
| TNM stage | |||||||
| I | 45 (9.5) | 20 (7.4) | 24 (12.7) | ||||
| II | 188 (39.7) | 115 (42.3) | 70 (37) | ||||
| III | 189 (39.9) | 109 (40.1) | 78 (41.3) | ||||
| IV | 46 (9.7) | 27 (9.9) | 16 (8.5) | ||||
| Tumor size | |||||||
| T < 5 cm | 275 (58) | 176 (64.7) | 96 (50.8) | ||||
| T ≥ 5 cm | 187 (39.5) | 92 (33.8) | 93 (49.2) |
CRC, colorectal cancer; SD, standard deviation; HTN, hypertension; DM, diabetes mellitus; Hcy, plasma homocysteine; TNM, tumor node metastasis.
*
P-values were calculated using chi-squared tests for categorical data and two–sided t-tests for continuous data.