Table 3.
HOTAIR polymorphism genotype frequencies and CRC patient 3-years mortality in overall, colon, and rectum cancer.
| Genotypes | Total CRC (n = 474) | Death (n = 74) | Adjusted HR(95% CI)† | P | Colon (n = 272) | Death (n = 43) | Adjusted HR (95% CI)† | P | Rectum (n = 189) | Death (n = 29) | Adjusted HR (95% CI)† | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HOTAIR rs7958904 G>C | ||||||||||||
| GG | 244 (51.5) | 40 (54.1) | 1.000 (reference) | 151 (55.5) | 27 (62.8) | 1.000 (reference) | 89 (47.1) | 11 (37.9) | 1.000 (reference) | |||
| GC | 191 (40.3) | 27 (36.5) | 0.891 (0.501–1.584) | 0.695 | 102 (37.5) | 13 (30.2) | 0.659 (0.299–1.452) | 0.304 | 84 (44.4) | 14 (48.3) | 1.797 (0.704–4.582) | 0.222 |
| CC | 39 (8.2) | 7 (9.5) | 2.995 (1.189–7.542) | 0.021 | 19 (7) | 3 (7) | 4.835 (1.094–21.376) | 0.039 | 16 (8.5) | 4 (13.8) | 6.076 (1.125–32.814) | 0.037 |
| Dominant | 1.070 (0.633–1.810) | 0.801 | 0.820 (0.401–1.675) | 0.587 | 2.039 (0.850–4.892) | 0.112 | ||||||
| Recessive | 2.583 (1.086–6.145) | 0.033 | 3.208 (0.877–11.738) | 0.080 | 3.383 (0.893–12.818) | 0.075 | ||||||
| HOTAIR rs1899663 G>T | ||||||||||||
| GG | 264 (55.7) | 45 (60.8) | 1.000 (reference) | 161 (59.2) | 29 (67.4) | 101 (53.4) | 15 (51.7) | 1.000 (reference) | ||||
| GT | 186 (39.2) | 23 (31.1) | 0.732 (0.401–1.336) | 0.312 | 100 (36.8) | 11 (25.6) | 0.499 (0.216–1.152) | 0.105 | 76 (40.2) | 11 (37.9) | 1.606 (0.619–4.171) | 0.333 |
| TT | 24 (5.1) | 6 (8.1) | 2.328 (0.876–6.185) | 0.092 | 11 (4) | 3 (7) | 4.507 (1.167–17.413) | 0.030 | 12 (6.3) | 3 (10.3) | 7.110 (0.831–60.815) | 0.075 |
| Dominant | 0.874 (0.508–1.503) | 0.627 | 0.691 (0.331–1.443) | 0.327 | 1.592 (0.668–3.792) | 0.296 | ||||||
| Recessive | 2.227 (0.871–5.693) | 0.096 | 4.468 (1.263–15.812) | 0.021 | 1.576 (0.316–7.866) | 0.581 | ||||||
| HOTAIR rs4759314 A>G | ||||||||||||
| AA | 395 (83.3) | 61 (82.4) | 1.000 (reference) | 229 (84.2) | 37 (86) | 159 (84.1) | 23 (79.3) | 1.000 (reference) | ||||
| AG | 71 (15) | 13 (17.6) | 1.102 (0.555–2.188) | 0.782 | 39 (14.3) | 6 (14) | 0.739 (0.276–1.979) | 0.549 | 28 (14.8) | 6 (20.7) | 1.462 (0.471–4.539) | 0.513 |
| GG | 8 (1.7) | 0 (0) | N/A | 0.991 | 4 (1.5) | 0 | N/A | 0.991 | 2 (1.1) | 0 | N/A | 0.990 |
| Dominant | 1.007 (0.507–1.997) | 0.985 | 0.694 (0.262–1.840) | 0.465 | 1.265 (0.406–3.938) | 0.687 | ||||||
| Recessive | N/A | 0.967 | N/A | 0.967 | N/A | 0.990 | ||||||
| HOTAIR rs920778 T>C | ||||||||||||
| TT | 258 (54.4) | 44 (59.5) | 1.000 (reference) | 149 (54.8) | 27 (62.8) | 102 (54) | 15 (51.7) | 1.000 (reference) | ||||
| TC | 180 (38) | 22 (29.7) | 0.754 (0.410–1.385) | 0.365 | 103 (37.9) | 12 (27.9) | 0.683 (0.310–1.505) | 0.347 | 73 (38.6) | 10 (34.5) | 1.208 (0.438–3.334) | 0.717 |
| CC | 36 (7.6) | 8 (10.8) | 3.639 (1.435–9.230) | 0.007 | 20 (7.4) | 4 (9.3) | 12.964 (2.216–75.858) | 0.005 | 14 (7.4) | 4 (13.8) | 3.925 (0.860–17.908) | 0.079 |
| Dominant | 0.985 (0.570–1.700) | 0.956 | 0.901 (0.440–1.844) | 0.776 | 1.493 (0.611–3.648) | 0.382 | ||||||
| Recessive | 3.481 (1.456–8.324) | 0.005 | 8.143 (1.946–34.084) | 0.004 | 3.383 (0.893–12.818) | 0.075 | ||||||
†
Adjusted for age, sex, hypertension, diabetes mellitus, tumor size, lymph node metastasis, chemotherapy, smoking, and alcohol based on Cox-regression analysis.