Figure 1.

Structure and organisation of microtubules. (A) Microtubule filaments are comprised of multiple dimeric complexes of α- and β-tubulin, assembled around a hollow core. Thirteen protofilaments assemble to form a microtubule. Microtubules are anchored at their minus ends at MTOCs, which is mediated by γ-tubulin. (B) Microtubules form dynamic networks in the cytoplasm which are stably anchored at MTOCs, including the centrosome and Golgi apparatus. Three-dimensional structural data: PDB ID tubulin dimer (1TUB).