Figure 3.

Lung dendritic cell subsets. Lung DCs are classified into conventional DC1s (cDC1s), cDC2s, and plasmacytoid DCs (pDCs). Each DC subset is widely distributed throughout the lungs and migrates to the lung-draining lymph node when they recognize RSV to initiate protective immune responses. cDC1s preferentially activate CD8⁺ T cells that mediate viral clearance, and cDC2s are responsible for Th2-mediated immune responses and RSV-mediated pulmonary diseases. pDCs are the main source of type I interferons (IFNs) and play an essential role in RSV-specific cytotoxic T lymphocyte (CTL) priming and regulation of disease severity. * Human-specific marker.