Figure 8.

miR-26a enhances IFN antiviral signalling by regulating downstream SOCS5 instead of interferon. F81 cells were co-transfected with miR-26a mimics together with siSOCS5#1 for 24 h and followed by FHV-1 infection (MOI = 1 for p-STAT1 expression analysis and MOI = 0.1 for virus titres analysis). At 24 hpi, p-STAT1 levels were detected by WB (A) and virus titres in supernatants were measured via plaque assay (B). All samples were independently repeated three times, and data are representative of three independent experiments. The significant differences are indicated as follows: NS > 0.05, * p < 0.05.