Table 1.
Effect of cisplatin and myricetin on glutathione dependent and other antioxidant enzymes.
| Group I | Group II | Group III | Group IV | |
|---|---|---|---|---|
| Reduced glutathione (GSH; nmol mg protein) | 343.87 ± 18.2 | 159.46 ± 14.2 *** | 181.76 ± 11.7 # | 321.08 ± 16.1 ### |
| Oxidized glutathione (GSSG; nmol mg protein) | 42.01 ± 4.76 | 81.32 ± 7.27 *** | 67.31 ± 5.01 # | 40.32 ± 4.34 ### |
| GSH/GSSG Ratio | 8.18 ± 0.82 | 1.96 ± 0.21 *** | 2.70 ± 0.33 # | 7.96 ± 0.61 ### |
| GPx (nmol/min/mg protein) | 211.81 ± 20.1 | 87.17 ± 9.24 *** | 117.62 ± 11.3 ## | 179.53 ± 16.3 ### |
| GR (nmol min/min/mg protein | 247.26 ± 19.8 | 98.32 ± 8.34 *** | 147.81 ± 10.3 ## | 213.53 ± 19.2 ### |
| G6PD (nmol NADP reduced/min/mg protein) | 234.27 ± 21.9 | 96.81 ± 9.51 *** | 149.90 ± 11.7 ## | 227.12 ± 20.1 ### |
| SOD (units/min/mg protein | 13.17 ± 1.34 | 4.87 ± 0.49 *** | 5.97 ± 0.91 # | 11.32 ± 2.23 ### |
| Catalase (nmol H2O2 consumed/min/mg protein | 10.37 ± 0.91 | 3.32 ± 0.12 *** | 5.32 ± 0.89 # | 9.11 ± 0.61 ### |
| H2O2 (nmol of H2O2/g tissue) | 164.2 ± 15.6 | 390.1 ± 32.9 *** | 319.1 ± 19.3 # | 210.7 ± 12.9 ### |
Values of these parameters were expressed as mean ± S.D. (n = 6). Significant differences were indicated by *** p < 0.001 when compared group II, and, # p < 0.01, ## p < 0.01 and ### p < 0.001 when compared with group II.