Table 2.

Animal models with hypertensive pregnancies and commonly reported renal injuries.

Model name	Host	Injury type	Renal injury characteristics	References
Dahl salt sensitive rat (Dahl-S)	Rat	Spontaneous and genetic	Antepartum—proteinuria, kidney injury via pathological scores, increases in glomerular area and diameter Postpartum—Proteinuria, increased neprhin excretion, kidney injury via pathological score, increased infiltration of renal T cells	(98, 99)
Renin-angiotensin system (RAS)	Mouse	Transgenic	Antepartum—increased albuminuria, kidney injury via pathological scores, decreased perfusion of glomeruli, glomerular endotheliosis, decreased number of erythrocytes in the capillary lumen of glomeruli	(100)
NG-nitro- L-arginine methyl ester (L-NAME)	Rat/mouse	Chemical	Antepartum—Proteinuria, increased blood urea nitrogen, increased serum creatinine, kidney injury via pathological scores	(101)
Reduced uterine perfusion pressure (RUPP)	Rat	Mechanical obstruction of ovarian and uterine arteries	Antepartum—decreased GFR, increased renal sympathetic nerve activity, decreased superoxide dismutase, proteinuria, reduced renal plasma flow Postpartum—decreased GFR	(102–105)