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. 2018 Jul 9;27(4):622–636. doi: 10.1177/0963689718771889

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 1. — Effects of sodium danshensu on expression of neurovascular regulatory factors.

The protein levels of VEGF, BDNF, SDF-1, and eNOS were detected by Western blot analysis. (A) Representative electrophoresis gels show the expression level of VEGF, BDNF, SDF-1, and eNOS in the ischemic peri-infarct region at 14 days after stroke. (B–E) densitometry analysis for comparisons of each factor. Gray intensity was normalized against tubulin and quantified by Image J software. Sodium danshensu enhanced the expression of VEGF, BDNF, SDF-1, and eNOS when compared with vehicle control group. n = 6 animals for each test. Data are shown as mean ± SEM.

^* P < 0.05 compared with sham group, ^# P < 0.05 compared with vehicle control group. VEGF: vascular endothelial growth factor; BDNF: brain-derived neurotrophic factor; SDF-1: stromal-derived factor-1; eNOS: endothelial nitric oxide synthase; SEM: standard error of the mean.