Table 2.

Proportion of muscle spasms at week 12 and week 20 after 12‐week treatment based on clinical trial simulations

Data frequency		Model	Any grade, median (95% CI)		Grade: 2/3, median (95% CI)
Estimation	Simulation		Week 12	Week 20	Week 12	Week 20
Weekly	Weekly	PO	0.64 (0.52–0.76)	0.09 (0.05–0.18)	0.29 (0.19–0.39)	0.01 (0.00–0.02)
		DTMM	0.69 (0.59–0.80)	0.14 (0.07–0.21)	0.20 (0.10–0.31)	0.01 (0.00–0.04)
		CTMM	0.73 (0.62–0.82)	0.10 (0.04–0.17)	0.20 (0.12–0.29)	0.00 (0.00–0.01)
Weekly	Daily	PO	0.63 (0.51–0.76)	0.09 (0.04–0.17)	0.29 (0.18–0.39)	0.01 (0.00–0.02)
		DTMM	0.86 (0.75–0.95)	0.02 (0.00–0.05)	0.32 (0.14–0.51)	0.00 (0.00–0.01)
		CTMM	0.73 (0.62–0.81)	0.10 (0.04–0.16)	0.20 (0.13–0.28)	0.00 (0.00–0.02)

CI, confidence interval; CTMM, continuous‐time Markov model; DTMM, discrete‐time Markov model; PO, proportional odds model.