Fig. 1.
Dosimetric factors and their association with the development of Symptomatic Radiation Pneumonitis. Abbreviations: MLD = Mean Lung Dose; Vdose is the percent of lung receiving greater than or equal to “dose” (in Gy). Symptomatic Radiation Pneumonitis = RTOG G3+ or CTCAE G2–3+ RP. Key: Boxes represent interquartile ranges of dose levels, stars represent mean dose, and circles represent outliers. Differences between asymptomatic patients and patients with symptomatic radiation pneumonitis are statistically significant at each radiation level for a) MLD, b) Total Vdose and c) select contralateral and ipsilateral values. The asymptomatic far outlier in panel B represent the same patient (see Table 7 and Individual Patient Data in the Appendix). All Vdose values in Panels B and C besides cV5 and iV40 hold statistical significance when evaluated as cubic centimeters (see Table 5, Figs. 3-4 in the Appendix)