Table 3.
Dose Volume Histogram Characteristics
| Characteristic | No Radiation Pneumonitis (n = 85) | Symptomatic Radiation Pneumonitis (n = 8) | P value |
|---|---|---|---|
| Contralateral Lung V5, % | |||
| Median | 3.1% | 7.4% | 0.05 |
| Range | 0.0–33.6% | 4.2–53.4% | |
| Ipsilateral Lung V30, % | |||
| Median | 3.3% | 9.6% | 0.001 |
| Range | 0.8–11.6% | 6.5–12.8% | |
| Ipsilateral Lung V40, % | |||
| Median | 2.1% | 5.8% | 0.003 |
| Range | 0.5–8.1% | 3.6–8.8% | |
| Total Lung V5, % | |||
| Median | 14.7% | 29.1% | 0.001 |
| Range | 4.2–46.9% | 18.2–56.9% | |
| Total Lung V10, % | |||
| Median | 8.4% | 21.7% | 0.001 |
| Range | 2.2–34.6% | 10.8–38.4% | |
| Total Lung V12.4, cm3 | |||
| Median | 223 cm3 | 372 cm3 | 0.004 |
| Range | 47–789 cm3 | 311–932 cm3 | |
| Total Lung V13.5, cm3 | |||
| Median | 195 cm3 | 333 cm3 | 0.004 |
| Range | 41–735 cm3 | 283–829 cm3 | |
| Total Lung V15, % | |||
| Median | 5.4% | 13.2% | 0.001 |
| Range | 1.2–25.8% | 7.8–18.8% | |
| Total Lung V20, % | |||
| Median | 3.4% | 9.1% | 0.001 |
| Range | 0.8–19.4% | 5.3–12.8% | |
| Total Lung V25, % | |||
| Median | 2.4% | 6.7% | 0.001 |
| Range | 0.6–15.2% | 3.6–9.6% | |
| Total Lung V30, % | |||
| Median | 1.8% | 5.1% | 0.002 |
| Range | 0.5–12.1% | 2.4–7.4% | |
| Total Lung V40, % | |||
| Median | 1.1% | 3.3% | 0.003 |
| Range | 0.3–8.6% | 1.1–4.7% | |
Abbreviations: Vdose is the percent of lung receiving greater than the “dose” (in Gy). Symptomatic Radiation Pneumonitis = RTOG G3+ or CTCAE G2+ RP
P-values from Wilcoxon Rank Sum tests, with all values Bonferroni adjusted. Bolded P-values indicate statistical significance