Table 1.

Nasal Airway Obstruction Study (NAIROS) eligibility criteria

Inclusion criteria

Exclusion criteria

• Adults aged ≥ 18 years • Baseline NOSE score ≥ 30 • Septal deflection at baseline visible via nasendoscopy • Capacity and willingness to provide written informed consent and complete the trial questionnaires

• Any prior septal surgery • Systemic inflammatory disease or the use of any current oral steroid treatment within the past 2 weeks • Granulomatosis with polyangiitis • Nasendoscopic evidence of unrelated associated pathology, e.g. adenoid pad, septal perforation, chronic rhinosinusitis indicated by the presence of polyposis or pus • Any history of intranasal recreational drug use within the past 6 months • Breast-feeding, pregnancy or intended pregnancy for the duration of involvement in the trial • Bleeding diathesis • Therapeutic anticoagulation (warfarin/novel oral anti-coagulant (NOAC) therapy) • Clinically significant contraindication to general anaesthesia • Patients known to be immuno-compromised • Those in whom an external bony deformity substantially contributes to the nasal obstruction