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. 2020 Feb 13;11:59. doi: 10.1186/s13287-020-1577-2

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The intrinsic deficiency of AA-MSCs. a Multiple genes associated with cell adhesion molecules (CAMs) were highly expressed in AA-MSCs, while cell cycle- and p53-associated genes were decreased in AA-MSCs. b The scratch analysis showed a decreased migration capacity of AA-MSCs (HD: n = 5; AA: n = 5). c, d The proliferative capacity of AA-MSCs was significantly decreased (HD: n = 5; AA: n = 5). e, f The cell cycle analysis showed a higher proportion in sub-G1 phase in AA-MSCs (HD: n = 8; AA: n = 8). g, h Significantly increased apoptotic cells was measured in AA-MSC by flow cytometry (HD: n = 6; AA: n = 6). i, j Increased cell senescence was observed in AA-MSCs by using β-GAL staining under light microscope and confocal microscope (HD: n = 5; AA: n = 5). k No karyotype abnormalities were observed in AA-MSCs (HD: n = 3; AA: n = 3)