Table 2.
BoNT therapy for post-parotidectomy gustatory hyperhidrosis, fistula, sialocele formation, and for post-parotidectomy sialorrhea.
| Authors | Design | Pts # | Clinical Problem | Injection Site |
Toxin and Dose | Result |
|---|---|---|---|---|---|---|
| Laskawi et al., 2013 [29] | R | 10 | Post-parotidectomy fistula | Parotid gland | OnaA 30–50 units |
Treated within 6 weeks of surgery: Fistulas healed in 9 of 10 patients |
| Marchese-Ragona et al., 2006 [30] | R | 3 | Post-parotidectomy fistula | Parotid gland | OnaA 15–20 units |
Complete healing of fistula with follow ups 12,18, and 14 months |
| Nolte et al., 2004 [31] | P | 20 | Gustatory sweating after parotidectomy | Facial skin | OnaA 3 units/cm |
Complete loss of sweating for 12 months |
| Kuttner et al., 2001 [32] | R | 8 | GH after parotidectomy | Face | BoNT-A 0.5 units/cm |
Stopped facial sweating within one week |
| Vargas et al., 2000 [33] | P | 4 | Post-parotidectomy sialocele-pain |
Parotid gland | OnaA 30–50 units |
Total resolution in 4 weeks in all patients |
| Steffen et al., 2014 [34] | R | 25 | Head and neck cancer FHS: (19) Fistula (6) |
Parotid gland | OnaA and incoA: Par: 30 U SM: 20 U | FHS: 11 of 19 improved. Fistula: 4 of 6 improved |
| Machese et al., 2008 [35] | R | 8 | Head and neck cancer sialorrhea: 6, fistula: 1, and sialocele: 1 | Parotid gland | AboA: 100 U |
Fistulas healed. Sialorrhea stopped |
| Eckardt et al., 2003 [36] | R | 33 | GH after parotidectomy | Face | OnaA 16 to 80 units |
Facial sweating disappeared within a week after injections |
| Cantarella and Barbieri [37] |
R | 7 | GH after parotidectomy | Face | RimaB 2200 units |
Cessation of sweating in 6 of 7 patients 4 weeks after injection |
| Matos Dias et al., 2008 [38] | R | 10 | GH after parotidectomy | Face | Ona-A 38 units |
Sweating stopped |
| Hatrl et al., 2008 [39] | R | 7 | GH after parotidectomy | Face | BoNT-A | Sweating and quality of life improved |
| Pomprasit et al., 2007 [40] | P | 9 | GH after Parotidectomy | Face | Ona-A 10.6 units |
Sweating stopped in 5 and reduced in 4 |
| Cavalot et al., 2000 [41] | P | 40 | GH after parotidectomy | Face | Ona-A, 2.5/cm2 | 100% response in severe group, 72% response in moderate group |
| Von Lindern et al., 2000 [42] | R | 7 | GH after parotidectomy | Face | Ona-A | Sweating stopped after BoNT injection |
| Laccourreye et al., 1998 [43] | P | 14 | GH after parotidectomy | Face | Ona-A | All showed total cessation of sweating |
| Bjerkhoel et al., 1997 [44] | P | 15 | GH after parotidectomy | Face | Ona-A | Total cessation of facial sweating in 13 patients |
Case reports are not included for salivary gland problems related to cancer surgery or cancer irradiation. R: Retrospective; P: Prospective; onaA: OnabotulinumtoxinA; incoA: IncobotulinumtoxinA; aboA: AbobotulinumtoxinA; FHS: Functional hypersalivation; Par: Parotid, SM: Submandibular.