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Schematic diagram depicting MetAP2 implication in different pathways. The scheme represents the normal functioning of cascades (black arrows) and the effect of MetAP2 inhibited by fumagillin (red discontinuous arrows). Fumagillin (F) binds covalently to MetAP2 and provokes the inhibition of G protein, SRC, and the ARF signaling pathway at different levels, and the protection of Rb and IF2 against phosphorylation (P).
