Table 1.
Composition of fumagillin biosynthetic cluster.
| Gene Name b | Other Gene Names c | Protein Abbreviated (Complete) Name d | UniProtKB d | Deletion Mutant | Ref. | |
|---|---|---|---|---|---|---|
| Afu8g00370 | fma-PKS |
af370
fmaB |
Fma-PKS (Fumagillin dodecapentaenoate synthase/Fumagillin biosynthesis polyketide synthase) | Q4WAY3 | Fumagillin production abolished Fumagillol production |
[28,62] |
| Afu8g00380 | fma-AT |
af380
fmaC |
Fma-AT (Polyketide transferase af380/Fumagillin biosynthesis acyltransferase) | Q4WAY4 | Fumagillin production abolished Fumagillol production |
[62] |
| Afu8g00390 /00400 | Afu8g00390 |
af390-400
fmaD |
Fma-MT (O-methyltransferase af390-400/Fumagillin biosynthesis methyltransferase) | A0A067Z9B6 | Fumagillin production abolished Demethyl-fumagillin production |
[28,63] |
| Afu8g00410 | metAP | fpaII | MAP2-1/MetAP2-1 (Methionine aminopeptidase 2-1/Peptidase M) | Q4WAY7 | [68] | |
| Afu8g00420 | fumR | fapR | FumR (C6 finger transcription factor fumR/Fumagillin gene cluster regulator) | Q4WAY8 | Fumagillin and pseurotin gene clusters silenced | [28,64] |
| Afu8g00430 | Afu8g00430 | (EthD domain-containing protein) | Q4WAY9 | [62,69] | ||
| Afu8g00440 | Afu8g00440 | psoF | PsoF (Baeyer-Villiger monooxygenase/Dual-functional monooxygenase/methyltransferase psoF/Pseurotin biosynthesis protein F) | Q4WAZ0 | Pseurotin production abolished | [28,62,69,70,71] |
| Afu8g00460 | Afu8g00460 | fpaI | (Methionine aminopeptidase) | Q4WAZ1 | [28,62] | |
| Afu8g00470 | Afu8g00470 |
af470
fmaE |
Fma-ABM (Monooxygenase af470/Fumagillin biosynthesis antibiotic biosynthesis monooxygenase superfamily monooxygenase) | Q4WAZ2 | Fumagillin production abolished Prefumagillin accumulation |
[28,62,63] |
| Afu8g00480 | Afu8g00480 |
af480
fmaF |
Fma-C6H (Dioxygenase af480/Fumagillin biosynthesis cluster C-6 hydroxylase) | Q4WAZ3 | Fumagillin production abolished 6-demethoxy-fumagillin accumulation |
[28,62,63] |
| Afu8g00490 | Afu8g00490 | af490 | Fma-KR (Stereoselective keto-reductase af490/Fumagillin biosynthesis cluster keto-reductase) | Q4WAZ4 | Fumagillin production strongly decreased | [62,63,72] |
| Afu8g00500 | Afu8g00500 | (Acetate-CoA ligase, putative) | Q4WAZ5 | [62,72] | ||
| Afu8g00510 | Afu8g00510 |
af510
fmaG |
Fma-P450 (Multifunctional cytochrome P450 monooxygenase af510/ Fumagillin biosynthesis cluster P450 monooxygenase) | Q4WAZ6 | Fumagillin production abolished, β-trans-bergamotene accumulation |
[28,62,63] |
| Afu8g00520 | fma-TC |
af520
fmaA |
Fma-TC (Fumagillin beta-trans-bergamotene synthase af520/Fumagillin biosynthesis terpene cyclase) | M4VQY9 | Fumagillin production abolished | [28,62] |