Table 2.

Literatures on effects of low fat diet on migraine headache

Authors and year	Type of article	Sample size	Type of diet	Duration of treatment	Results
Ferrara LA, Pacioni D, Di Fronzo V, Russo BF, Speranza E, Carlino V, et al. 2015 [53]	Crossover intervention trial	83 episodic or chronic migraineurs (63 female and 20 male)	a low-lipid and a normal-lipid diet	3 months + 3 months	Significant reduction in severity and number of migraine attacks
Ramsden CE, Zamora D, Faurot KR, et al. 2013	randomized trial	67 patients with chronic daily headache (H3-L6 = 33, L6 = 34)	High omega-3 + low omega-6 fatty acid (H3-L6) or low omega-6 fatty acid (L6)	12 weeks	Significant reduction in HIT score, headaches day per month, and headache hours per day in H3-L6 group
Bic Z, Blix GG, Hopp HP, Leslie FM, Schell MJ. 1999 [135]	Clinical trial	54 migraineurs	limit fat intake to no more than 20 g/day	12 weeks	Significant decrease in headache frequency, intensity, and duration and medication intake
Bunner AE, Agarwal U, Gonzales JF, Valente F, Barnard ND. 2014	Crossover trial	42 migraineurs	dietary instruction (a low-fat vegan diet) and placebo supplement	36 weeks (16 weeks + 4 weeks washout+ 16 weeks)	Significant reduction in headache severity and frequency during the diet period