Table 1.
Demographic and anthropometric characteristics and co-morbidities of RA patients
| Anti-CCP negative (N = 55) | Anti-CCP positive (N = 109) | p value | Total (N = 164) | |
|---|---|---|---|---|
| Gender | 0.815 | |||
| Female | 42 (76%) | 85 (78%) | 127 (77%) | |
| Male | 13 (24%) | 24 (22%) | 37 (23%) | |
| Ratio F/M | 3.4 | |||
| Mean age (SD) years | 54.9 (9.79) | 53.7 (10.81) | 0.490 | 54.1 (10.46) |
| Race | ||||
| Caucasian | 54 (98%) | 105 (96%) | 0.723 | 159 (97%) |
| Graffar | 0.064 | |||
| High | 1 (2%) | 10 (9%) | 11 (6%) | |
| Medium | 17 (31%) | 16 (14%) | 33 (20%) | |
| Low | 21 (38%) | 39 (36%) | 62 (37%) | |
| Relative poverty | 14 (25%) | 38 (35%) | 52 (32%) | |
| Extreme poverty | 2 (4%) | 6 (6%) | 8 (5%) | |
| Annual dental prophylaxis | 29 (54%) | 42 (39%) | 0.066 | 71 (44%) |
| Median ESR (P25;P75) (mm/h) | 19.5 (9.8; 32.0) | 26.0 (16.5; 36.5) | 0.017 | 24.0 (12.0; 34.0) |
| Median CRP (P25;P75) (mg/L) | 2.8 (1.2; 5.0) | 3.4 (1.62; 7.3) | 0.077 | 3.4 (1.4; 6.2) |
| Bone mineral density | 0.624 | |||
| Normal | 21 (48%) | 34 (41%) | 55 (43%) | |
| Osteopenia | 15 (34%) | 28 (34%) | 43 (34%) | |
| Osteoporosis | 8 (18%) | 21 (25%) | 29 (23%) | |
| Tobacco | 0.709 | |||
| Never | 30 (54%) | 59 (54%) | 89 (54%) | |
| Former smoker | 13 (24%) | 31 (28%) | 44 (27%) | |
| Current | 12 (22%) | 19 (17%) | 31 (19%) | |
| Stress | 9 (17%) | 36 (33%) | 0.028 | 45 (28%) |
| Diabetes (total) | 10 (18%) | 8 (7%) | 0.036 | 18 (11%) |
| Type II | 9 (16%) | 6 (5%) | 0.074 | 15 (9%) |
| Dyslipidemia | 27 (49%) | 56 (51%) | 0.318 | 83 (50%) |
| Hypercholesterolemia | 12 (22%) | 31 (28%) | 43 (26%) | |
| Hypertriglyceridemia | 4 (7%) | 13 (12%) | 17 (10%) | |
| Mixed hyperlipidemia | 11 (20%) | 12 (11%) | 23 (14%) | |
| Hypertension | 18 (33%) | 33 (30%) | 0.749 | 51 (31%) |
| Myocardial infarction | 2 (4%) | 5 (5%) | 0.776 | 7 (4%) |
| Mean BMI (SD) (kg/m2) | 27.1 (3.69) | 28.1 (5.20) | 0.174 | 27.8 (4.8) |
| Categories | 0.026 | |||
| Normal, 18.5–24.99 | 14 (25%) | 33 (30%) | 47 (29%) | |
| Overweight, 25–29.99 | 30 (55%) | 38 (35%) | 68 (41%) | |
| Obesity I, 30–34.99 | 11 (20%) | 28 (26%) | 39 (24%) | |
| Obesity II, ≥ 35 | – | 10 (9%) | 10 (6%) | |
Data represent numbers, percentages, mean (SD), or median (P25; P75)
Anti-CCP anti-cyclic citrullinated peptide, BMI body mass index, CRP C-reactive protein, ESR, erythrocyte sedimentation rate, RA rheumatoid arthritis, SD standard deviation