. 2020 Feb 13;20:40. doi: 10.1186/s12890-020-1079-0

Table 2.

Association between CHCHD2 and HIF-1α protein expressions and clinicopathological features in NSCLC patients

Clinicopathologic features	n = 209	CHCHD2 expression						HIF-1α expression
Clinicopathologic features	n = 209	–	+	++	+++	Z	P-value	–	+	++	+++	Z	P-value
Gender
Male	157	11	63	70	12	−1.478	0.139	8	39	94	16	−1.371	0.170
Female	52	0	18	29	5	−1.478	0.139	1	9	36	6	−1.371	0.170
Age (years)
≥62	107	7	37	56	7	−0.573	0.567	5	23	66	13	−0.599	0.549
< 62	102	4	45	45	8	−0.573	0.567	4	25	64	9	−0.599	0.549
Smoking
Yes	132	10	54	61	7	−2.001	0.045	8	36	74	14	−2.114	0.035
No	77	1	28	40	8	−2.001	0.045	1	12	56	8	−2.114	0.035
Tumor position
Periphery type	73	3	34	31	5	−1.024	0.306	4	14	50	5	−0.162	0.871
Central type	136	8	48	70	10	−1.024	0.306	5	34	80	17	−0.162	0.871
Tumor size (cm)
>5	109	5	27	69	8	−3.916	0.000	5	23	68	13	−0.692	0.489
≤5	100	6	55	32	7	−3.916	0.000	4	25	62	9	−0.692	0.489
Tumor category
Adenocarcinoma	82	2	29	44	7	−1.738	0.082	2	12	59	9	−2.213	0.027
Squamous caner	127	9	53	57	8	−1.738	0.082	7	36	71	13	−2.213	0.027
Differentiation degree
Well/ Moderate	152	8	66	70	8	−2.122	0.034	7	42	91	12	−2.939	0.003
Poor	57	3	16	31	7	−2.122	0.034	2	6	39	10	−2.939	0.003
TNM Stage
Ia-IIa	116	9	68	38	1	−7.279	0.000	8	33	66	9	−3.093	0.002
IIb -IIIb	93	2	14	63	14	−7.279	0.000	1	15	64	13	−3.093	0.002
Lymph metastasis
metastasis	116	4	33	65	14	−4.468	0.000	3	20	77	16	−2.967	0.003
Non-metastasis	93	7	49	36	1	−4.468	0.000	6	28	53	6	−2.967	0.003