Table 4.
The correlation of CHCHD2 with HIF-1α protein expression in NSCLC
| Group | CHCHD2 | HIF-1α | ||||||
|---|---|---|---|---|---|---|---|---|
| – | + | ++ | +++ | rs | P-value | |||
| NSCLC | – | 7 | 2 | 2 | 0 | 0.526 | 0.000 | |
| + | 1 | 35 | 43 | 3 | ||||
| ++ | 1 | 11 | 80 | 9 | ||||
| +++ | 0 | 0 | 5 | 10 | ||||
| Histological type | ||||||||
| Adenocarcinoma | – | 1 | 0 | 1 | 0 | 0.447 | 0.000 | |
| + | 1 | 9 | 18 | 1 | ||||
| ++ | 0 | 4 | 37 | 4 | ||||
| +++ | 0 | 0 | 3 | 4 | ||||
| Squamous caner | – | 6 | 2 | 1 | 0 | 0.548 | 0.000 | |
| + | 0 | 26 | 25 | 2 | ||||
| ++ | 1 | 8 | 43 | 5 | ||||
| +++ | 0 | 0 | 2 | 6 | ||||
| Differentiation | ||||||||
| High/ Moderate | – | 5 | 2 | 1 | 0 | 0.550 | 0.000 | |
| + | 1 | 31 | 34 | 0 | ||||
| ++ | 1 | 9 | 54 | 6 | ||||
| +++ | 0 | 0 | 2 | 6 | ||||
| Poor | – | 2 | 0 | 1 | 0 | 0.380 | 0.004 | |
| + | 0 | 4 | 9 | 3 | ||||
| ++ | 0 | 2 | 26 | 3 | ||||
| +++ | 0 | 0 | 3 | 4 | ||||
| Lymph node metastasis | ||||||||
| Lymph metastasis | – | 2 | 1 | 1 | 0 | 0.515 | 0.000 | |
| + | 1 | 12 | 18 | 2 | ||||
| ++ | 0 | 7 | 53 | 5 | ||||
| +++ | 0 | 0 | 5 | 9 | ||||
| Non-Lymph metastasis | – | 5 | 1 | 1 | 0 | 0.494 | 0.000 | |
| + | 0 | 23 | 25 | 1 | ||||
| ++ | 1 | 4 | 27 | 4 | ||||
| +++ | 0 | 0 | 0 | 1 | ||||