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. 2020 Feb 7;10:105. doi: 10.3389/fonc.2020.00105

Figure 1.

Figure 1

microRNA expression changes with disease course in MPM. The expression of most miRNAs is lower in MPM than normal mesothelium (NM) levels, and is shown schematically for three representative groups (levels are shown relative to NM, and are in arbitrary units for illustrative purposes). Some miRNAs are found at lower levels in tumors with poor prognosis (e.g., miR-215 and miR-193a) which may indicate a continuing gradual decrease in expression with tumor progression (indicated by decreasing levels in A). Others, such as miR-15/16 and the miR-34 family are consistently decreased in MPM samples but do not appear to have prognostic value, suggesting they do not change with advanced stage (B). Another group, exemplified by miR-31 and miR-17, exhibit lower levels in MPM compared with NM, but are also higher in patients with shorter survival, possibly indicating an increase in expression with tumor progression (C).