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. 2020 Feb 7;11:33. doi: 10.3389/fphys.2020.00033

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Copyright © 2020 Wu, Lin, Lin, Rao, Lin, Wu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mRNA levels of Cx43-, fibrosis-, and pro-inflammatory cytokine-related proteins. Rat myocardium with ischemic injury showed increased mRNA levels of TGF-β, collagen-I, collagen-III, and pro-inflammatory cytokines and significantly lower levels of Cx43 mRNA. Rats treated with Dex showed a tendency to present lower levels of fibrosis and pro-inflammatory mRNAs than did those in the ICM group. Dex significantly increased Cx43 mRNA levels in the ICM + Dex group. BML attenuated the effects of Dex on mRNA levels. Data are expressed as mean ± SD. *p < 0.05 vs. Sham group, #p < 0.05 vs. ICM group, ▲p < 0.05 vs. ICM + Dex group (n = 6 for each group).