Table 2.
Cluster of SMP-DCM network.
| Cluster | Score | Nodes | Edges | Targets and genes |
|---|---|---|---|---|
| 1 | 40.981 | 54 | 1086 | ICAM1, SERPINE1, IGF1, JAK2, CALM1, AKT1, CALM2, CALM3, GRB2, EDN1, TP53, LCK, MAPK14, CDKN2A, CAT, KDR, CTGF, IL1B, KIT, CCL2, NOS1, ANXA5, REN, RHOA, SPP1, IL2, NR3C1, INS, PIK3CG, HRAS, LEP, ABL1, TNF, TLR4, CASP3, CSF3, ESR1, EGFR, MMP2, MAPK1, SRC, ACE, HSP90AA1, MAP2K1, KNG1, HPGDS, CDC42, BCL2L1, MMP9, F2, PARP1, PLG, RAF1, PPARG |
| 2 | 13.25 | 41 | 265 | PTK2, ADIPOQ, LPL, CDK2, BDNF, AR, CRP, TNFSF11, PLAT, SOCS3, XIAP, ALB, INSR, HBA1, PTPN11, SLC2A4, MMP3, AGT, PGR, RAC2, IGF1R, SYK, CSK, AGTR1, MAPK8, STAT1, NOS2, FN1, MMP1, MDM2, CASP1, GSK3B, HMOX1, NOS3, TF, HCK, FOXO1, SELE, CCL5, RETN, PLAU |
| 3 | 6.571 | 8 | 23 | GSTO1, CYP2C9, CYP2C8, GSTM1, PLA2G2A, GSTA3, GSTA1, GSTM2 |
| 4 | 4.375 | 33 | 70 | MET, FGF1, F7, SIRT1, PRKCQ, MAPK12, PGF, SOCS1, RAC1, CDK6, EIF4E, CD36, GSR, PIK3R1, HDAC1, ZAP70, SOD2, BTK, TXN, GJA1, APAF1, CASP7, PRKCB, PTPN1, SELP, PPARA, HSPA8, ETS1, DUSP1, APOB, ERBB4, TEK, LYZ |
| 5 | 4 | 6 | 10 | TXN2, CLPP, GPI, IMPDH2, AK1, TPI1 |
| 6 | 4 | 6 | 10 | GART, HPRT1, CDA, NT5M, TK1, DTYMK |
| 7 | 3.512 | 42 | 72 | ACE2, PDE5A, RLN3, APLN, PLK1, GLRX, NFE2L2, GMPR, GC, CTNNA1, GSTP1, CSNK2A1, RND3, S1PR3, DPP4, HSP90AB1, APOA2, HSPD1, CRYZ, GMPR2, YWHAQ, PDPK1, FKBP1A, TGFBR1, HSPE1, GP1BA, EDN2, GCK, BDKRB2, CMA1, BDKRB1, AKR1B1, PPP1CC, CP, PAK6, APLNR, TYMS, ACO1, ALDH2, HP, PRDX2, IMPDH1 |
| 8 | 3.5 | 13 | 21 | NQO1, STK11, SOD1, ELANE, BECN1, KEAP1, SERPINA1, MMP7, LGALS3, ATIC, CTSS, CTSB, RHEB |
| 9 | 3.222 | 19 | 29 | ADK, ME2, NNT, PDHB, PKLR, PROC, AHCY, G6PD, ARF4, F11, APRT, DHFR, SHMT1, PSPH, F10, SDS, MTAP, NME2, ACADM |
| 10 | 3 | 3 | 3 | RAB5A, TFRC, RAB11A |
| 11 | 3 | 5 | 6 | LPA, RBP4, AHSG, FGG, TTR |
| 12 | 3 | 3 | 3 | GSTZ1, FTH1, NR1H2 |
| 13 | 3 | 3 | 3 | RARG, CRABP2, RARB |
| 14 | 2.667 | 7 | 8 | SORD, AKR1C2, AKR1C3, AKR1C1, AMY1A, HK1, PYGL |