Table 1. Relative helix nucleation in 27–40 by cycles 5–25 a .
# | Sequence | Cycle | f H (buffer) | [θ222]/[θ208] |
27 | Ac-cyclo-[DAADap]-(ARL)3-NH2 | 5 | 0.42 | 1.15 |
28 | Ac-cyclo-[DAADab]-(ARL)3-NH2 | 6 | 0.31 | 0.84 |
29 | Ac-cyclo-[DAAO]-(ARL)3-NH2 | 7 | 0.29 | 0.74 |
30 | Ac-cyclo-[DapAAE]-(ARL)3-NH2 | 9 | 0.29 | 0.73 |
31 | Ac-cyclo-[EAADap]-(ARL)3-NH2 | 13 | 0.42 | 0.85 |
32 | Ac-cyclo-[EAAO]-(ARL)3-NH2 | 15 | 0.36 | 0.75 |
33 | Ac-cyclo-[dAADap]-(ARL)3-NH2 | 17 | 0.54 | 0.98 |
34 | Ac-cyclo-[eAADap]-(ARL)3-NH2 | 18 | 0.45 | 0.96 |
35 | Ac-cyclo-[dAAO]-(ARL)3-NH2 | 20 | 0.36 | 0.77 |
36 | Ac-cyclo-[isoDAADap]-(ARL)3-NH2 | 21 | 0.66 | 1.08 |
37 | Ac-cyclo-[isodAADap]-(ARL)3-NH2 | 22 | 0.61 | 0.98 |
38 | Cyclo-[SuccAADap]-(ARL)3-NH2 | 23 | 0.65 | 1.03 |
39 | Cyclo-[GlutAADap]-(ARL)3-NH2 | 24 | 0.52 | 0.91 |
40 | Ac-cyclo-[KAAAD]-(ARL)3-NH2 | 25 | 0.59 | 1.02 |
a10 mM phosphate buffer (pH 7.4, 25 °C), [peptide] = 125 μM.