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. Author manuscript; available in PMC: 2020 Feb 14.
Published in final edited form as: Parkinsonism Relat Disord. 2019 Jan 9;59:9–20. doi: 10.1016/j.parkreldis.2019.01.009

Figure 5. Towards a symptom-segregated model.

Figure 5.

The tripartite, or segregated, model of the basal ganglia describes the anatomical separation of sensorimotor, limbic, and associative pathways. It is now recognized that the division of labor in the basal ganglia may not be so distinct and can instead be considered a continuum with overlapping boundaries. Nonetheless, there is now a shift towards a symptom-segregated model, in which specific brain targets at the millimeter or submillimeter scale are chosen to address specific predominant symptoms. Adapted from Eisinger et al., 2018. Front. Neurosci. - https://doi.org/10.3389/fnins.2018.00385 [119] with permission.