Table 1.
In vitro activities of aztreonam/avibactam against MBL-producing K. pneumoniae
| Strains (n) | CAZ |
IPM |
ATM |
CAZ/AVI |
ATM/AVI |
ATM/CAZ/AVI |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | MIC range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | MIC range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | MIC range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | MIC range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | MIC range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | |
| All (68) | 128 to >128 | >128 | >128 | 4 to >32 | >32 | >32 | ≤0.5 to >128 | >128 | >128 | 16 to >64 | >64 | >64 | ≤0.25–8 | ≤0.25 | 1 | ≤0.125 | ≤0.125 | ≤0.125 |
| Single MBL (55) | 128 to >128 | >128 | >128 | 4 to >32 | 32 | >32 | ≤0.5 to >128 | >128 | >128 | 64 to >64 | >64 | >64 | ≤0.25–1 | ≤0.25 | 0.5 | ≤0.125 | ≤0.125 | ≤0.125 |
| Dual/triple carbapenemases (13) | >128 | >128 | >128 | 8 to >32 | >32 | >32 | ≤0.5 to >128 | >128 | >128 | 16 to >64 | >64 | >64 | ≤0.25–8 | 0.5 | 8 | ≤0.125 | ≤0.125 | ≤0.125 |
CAZ, ceftazidime; IPM, imipenem; ATM, aztreonam; AVI, avibactam.