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Time–kill kinetics of tedizolid against M. abscessus CIP 104536. (a) Dose–response of tedizolid (MIC = 4 mg/L). (b) Combination time–kill kinetics of tedizolid and amikacin (MIC = 32 mg/L). (c) Percentage of the 5× MIC amikacin-resistant subpopulation of (b). (d) Percentage of the 5× MIC linezolid-resistant subpopulation of (b). AMK, amikacin; LZD, linezolid; TZD, tedizolid.
