Table 2.
FICIs of tedizolid in combination with clarithromycin, cefoxitin, tigecycline or amikacin for RGM, and tedizolid in combination with clarithromycin, rifampicin, ethambutol, amikacin or minocycline for M. avium
|
M. abscessus (n = 5) |
M. fortuitum (n = 1) | M. peregrinum (n = 1) | M. chelonae (n = 1) | ||
|---|---|---|---|---|---|
| Combination | average FICI | range (min–max) | FICI | FICI | FICI |
| Tedizolid/clarithromycin | 0.53 | 0.28–0.625 | 0.75 | 1 | 1 |
| Tedizolid/cefoxitin | 0.81 | 0.56–1 | 0.375 | 0.625 | 0.5 |
| Tedizolid/tigecycline | 1.01 | 0.56–1.25 | 1 | 0.375 | 0.625 |
| Tedizolid/amikacin | 0.75 | 0.56–1 | 0.75 | 0.5 | 0.75 |
|
| |||||
|
MAC (n = 4) |
|||||
| Combination | average FICI | range (min–max) | |||
|
| |||||
| Tedizolid/clarithromycin | 1 | 0.75–1.25 | |||
| Tedizolid/rifampicin | 1.25 | 0.5–2.5 | |||
| Tedizolid/ethambutol | 0.72 | 0.5–1 | |||
| Tedizolid/amikacin | 0.81 | 0.5–1 | |||
| Tedizolid/minocycline | 0.78 | 0.625–1 | |||