TABLE 2.

Univariate and Multivariable Analysis for Recurrence Free Survival (RFS) and Overall Survival (OS)

	RFS				OS
	Univariate		Multivariable		Univariate		Multivariable
Parameter	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age at diagnosis	0.990 (0.968–1.013)	0.3978			1.022 (0.993–1.052)	0.1461	1.035 (1.002–1.070)	0.0403
Ki-67 index	1.045 (1.029–1.062)	<0.0001	1.024 (1.005–1.043)	0.0116	1.039 (1.016–1.062)	0.0007
Male vs Female	1.479 (0.749–2.921)	0.2598			1.017 (0.480–2.155)	0.9651
NET G1 vs NET G3/NEC	0.023 (0.005–0.106)	<0.0001			0.085 (0.025–0.288)	<0.0001
NET G2 vs NET G3/NEC	0.157 (0.073–0.338)	<0.0001			0.168 (0.070–0.402)	<0.0001
LVI, yes/no	10.733 (4.169–27.630)	<0.0001	5.133 (1.607–16.394)	0.0058	5.215 (1.980–13.736)	0.0008	3.592 (1.198–10.768)	0.0225
PNI, yes/no	3.903 (1.947–7.825)	0.0001			2.518 (1.176–5.393)	0.0175
Tumor growth pattern, infiltrative vs circumscribed	7.304 (3.727–14.313)	<0.0001	2.814 (1.211–6.538)	0.0162	4.372 (2.038–9.375)	0.0002	2.720 (1.150–6.433)	0.0227
Intratumoral fibrosis, yes/no	2.924 (1.438–5.947)	0.0031			1.709 (0.783–3.731)	0.1787
Whipple vs non-Whipple					1.397 (0.661–2.953)	0.3807
Tumor size	1.050 (0.956–1.154)	0.3701			0.964 (0.830–1.118)	0.6247