Figure 7. Summary of impact of individual gene mutations on survival.

TP53 gain-of-function (GOF) and frameshift (FS) mutations and PIK3CA mutations were associated with worse survival, while tumors with no mutations demonstrated more favorable survival. HRs are –Log2 transformed so that a HR of 2 equals 1.0 and a HR of 0.5 equals -1.0. ^**** p-value < 0.0001; ^*** p-value < 0.001; ^** p-value < 0.01, ^* p-value < 0.05. Since response to ICB was not interrogated in this relationships, all 554 patients were included in this analysis regardless of treatment status.