Extended Data Figure 7. Indel signatures in the sample set.

(A) Five indel signatures were extracted by the hierarchical Dirichlet process. Contribution of different types of indels to each signature are shown, grouped by whether variants are deletions or insertions; size of event; whether they occur at repeat units; and the sequence content of the indel.

(B) Stacked bar-plot showing the proportional contribution of mutational signatures to indels across the 632 colonies derived from normal bronchial cells, extracted using a hierarchical Dirichlet process. Within each patient, colonies are sorted from left to right by increasing indel burden (bar chart in dark grey above coloured signature attribution stacks).