Extended Data Figure 9. Driver mutations in normal bronchial epithelium.

(A) Stick plots showing distribution of mutations in TP53, NOTCH1 and other genes that were significantly mutated in our sample set – mutations are coloured by type. The gene structure is shown horizontally in the centre of each plot with domains as coloured bars. Above the gene are mutations in this sample set; below the gene are the mutations found in squamous cell carcinomas from the TCGA sample set.

(B) Fraction of cells with driver mutations in TP53 (left), NOTCH1 (middle) or all other significant cancer genes (right), split by smoking status.