Extended Data Table 2.

Summary table of findings from live imaging of native HSCs vs. transplanted HSCs.

Native HSCs (this work)	Transplanted HSCs
Adjacent to both endosteum and sinusoidal blood vessels	Adjacent to both endosteum and blood vessels (did not identify type) (Lo Celso C et al, Nature 2009)
Do not reside in regions with deepest hypoxia	Do not home in regions with deepest hypoxia (Spencer JA et al, Nature 2014)
Sessile; become motile after activation	Sessile; become motile after activation (Rashidi NM et al, Blood 2014)
Proliferate and form clusters after Cy/GCSF or 5-FU	Proliferate and form clusters after transplantation (Lo Celso C et al, Nature 2009)