Table 3.
Factor Associated with Progressive or Recurrent to CIN2 or Worse
| Variables | N | Progressive/ recurrent CIN2+ (%) |
Crude HR | 95% CI | P-value | Adjusted HR | 95% CI | P-value | |
|---|---|---|---|---|---|---|---|---|---|
| Age | |||||||||
| < 35 yrs. | 62 | 2 | (3.2) | ||||||
| > 35 yrs. | 125 | 18 | (14.4) | 4.86 | (1.13-20.97) | 0.034* | 5.8 | (1.34-25.08) | 0.019* |
| Parity | |||||||||
| Nulliparity | 33 | 3 | (9.1) | ||||||
| Multiparity | 154 | 17 | (11) | 1.41 | (0.41-4.84) | 0.588 | |||
| HIV infection | |||||||||
| No | 170 | 20 | (11.8) | ||||||
| Yes | 17 | 0 | 0 | ||||||
| Smoking | |||||||||
| No | 184 | 20 | (10.9) | ||||||
| Yes | 3 | 0 | 0 | ||||||
| Initial histology | |||||||||
| LSIL | 108 | 7 | (6.5) | ||||||
| HSIL | 79 | 13 | (16.5) | 2.8 | (1.12-7.03) | 0.028* | |||
| p16 IHC staining | |||||||||
| Negative | 96 | 4 | (4.2) | ||||||
| Positive | 91 | 16 | (17.6) | 4.65 | (1.55-13.93) | 0.006* | 5.33 | (1.77-16.01) | 0.003* |
| Treatment | |||||||||
| Observation | 105 | 10 | (9.5) | ||||||
| LEEP | 79 | 9 | (11.4) | 1.27 | (0.52-3.13) | 0.6 | |||
| Hysterectomy | 3 | 1 | (33.3) | 4.42 | (0.56-34.73) | 0.158 | |||
CIN2+, cervical intraepithelial neoplasia 2 or worse; HSIL, high-grade squamous intraepithelial lesion; LEEP, loop electrosurgical excision procedure; LSIL, low-grade squamous intraepithelial lesion; p16 IHC, p16 protein-immunohistochemistry; * Significance at p-value less than 0.05; †, Student t-test; ‡, Chi-square test, §Fisher-exact test