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. 2020 Feb 14;10:2651. doi: 10.1038/s41598-020-59397-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differences in the haplotype profiles, both pre- and post-treatment on daclatasvir/asunaprevir and simeprevir. (A) The graph demonstrates the differences in the number of haplotype codes between pre-and post-treatment with daclatasvir/asunaprevir (DCV/ASV). The x-axis represents the timepoint of the sera collection, and the y-axis represents the number of haplotypes. The Wilcoxon signed-rank test was used for the statistical examination of the difference between the number of haplotype codes. (B) The graph demonstrates the difference in the number of nonsynonymous codons per clone from pre-treatment of DCV/ASV to post-treatment. The x-axis represents the timepoint of the sera collection and the y-axis represents the mean number of nonsynonymous codons on the 7-RAS loci, per HCV clone. The Wilcoxon signed-rank test was used for the statistical examination of the differences between the number of nonsynonymous codons. (C) The graph demonstrates the differences in the number of haplotype codes between pre-and post-treatment with simeprevir (DCV/ASV). The x-axis represents the timepoint of the sera collection, and the y-axis represents the number of haplotypes. (D) The graph demonstrates the difference in the number of nonsynonymous codons per clone from the pre-treatment of SMV to the post-treatment. The x-axis represents the timepoint of the sera collection and the y-axis represents the mean number of nonsynonymous codons on the 7 RAS loci, per HCV clone.