Table 1.
Demographic and clinical parameters for psychosis probands, their nonpsychotic relatives, and healthy controls.
| Probands (N = 326) |
Relatives (N = 315) |
Healthy controls (N = 202) |
F | p | |
|---|---|---|---|---|---|
| Mean (standard deviation) | |||||
| Age (years) | 35.35 (12.45) | 39.83 (15.68) | 36.59 (12.55) | 8.85 | <0.001 |
| Education | 13.59 (2.41) | 14.32 (2.64) | 14.96 (2.39) | 19.25 | <0.001 |
| GAF | 53.50 (13.96) | 77.08 (12.39) | 86.65 (6.54) | 555.03 | <0.001 |
| WRAT | 100.22 (15.13) | 101.25 (15.03) | 103.64 (14.10) | 3.36 | 0.035 |
| BACS | −1.19 (1.40) | −0.32 (1.21) | 0.02 (1.11) | 67.69 | <0.001 |
| PANSS_Total | 64.21 (17.42) | ||||
| PANSS_Positive | 16.33 (5.53) | ||||
| PANSS_Negative | 14.81 (5.44) | ||||
| YMRS_Total | 6.47 (6.27) | ||||
| MADRS_Total | 11.38 (9.33) | ||||
| CPZ dose (mg/day) | 406.31 (381.37) | ||||
| N (%) | N (%) | N (%) | χ2 | P | |
|---|---|---|---|---|---|
| Sex (male, %) | 143 (43.9%) | 91 (28.9%) | 88 (43.6%) | 18.46 | <0.001 |
| Handed (right, %) | 273 (83.7%) | 272 (86.3%) | 177 (87.6%) | 2.48 | 0.648 |
| Race | |||||
| Caucasian | 190 (58.3%) | 214 (67.9%) | 134 (66.3%) | 12.19 | 0.016 |
| African American | 115 (35.3%) | 86 (27.3%) | 50 (24.8%) | ||
| Other | 21 (6.4%) | 15 (4.8%) | 18 (8.9%) |
BACS Brief Assessment of Cognition in Schizophrenia (z-score), CPZ Chlorpromazine Equivalent Antipsychotic Dosage, GAF Global Assessment of Functioning, MADRS Montgomery-Åsberg Depression Rating Scale, PANSS Positive and Negative Syndrome Scale, WRAT wide-range achievement test, YMRS Young Mania Rating Scale