Table 2.
Network metrics of regions showing significant intergroup differences in psychotic probands and their nonpsychotic relatives.
| Regions with altered network metrics | Nodal centrality metrics | Probands (N = 326)/relatives (N = 315) |
HC (N = 202) | ANCOVA | |
|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | F | P* | ||
| Psychotic probands vs healthy controls | |||||
| STG, L | Efficiency | 0.042 ± 0.012 | 0.045 ± 0.009 | 11.36 | 0.024 |
| STP, L | Efficiency | 0.055 ± 0.006 | 0.056 ± 0.004 | 10.37 | 0.031 |
| STP, R | Efficiency | 0.056 ± 0.006 | 0.058 ± 0.005 | 11.99 | 0.024 |
| MTG, L | Efficiency | 0.059 ± 0.005 | 0.060 ± 0.004 | 9.55 | 0.038 |
| Nonpsychotic relatives vs healthy controls | |||||
| MFG, R | Degree | 3.67 ± 0.58 | 3.89 ± 0.60 | 10.43 | 0.009 |
| IFG_Orb, R | Degree | 3.07 ± 0.81 | 3.30 ± 0.57 | 12.93 | 0.006 |
| PCG, L | Degree | 3.11 ± 1.58 | 2.49 ± 1.49 | 17.17 | 0.004 |
| Hippocampus, L | Degree | 6.18 ± 0.75 | 6.40 ± 0.62 | 12.57 | 0.006 |
| Pallidum, L | Degree | 7.58 ± 1.16 | 7.93 ± 0.73 | 12.42 | 0.006 |
| Thalamus, L | Degree | 3.42 ± 0.79 | 3.17 ± 0.55 | 12.39 | 0.006 |
| MFG, R | Efficiency | 0.067 ± 0.004 | 0.069 ± 0.004 | 9.52 | 0.013 |
| IFG_Orb, R | Efficiency | 0.062 ± 0.006 | 0.064 ± 0.004 | 9.07 | 0.018 |
| PCG, L | Efficiency | 0.065 ± 0.010 | 0.061 ± 0.009 | 14.12 | 0.003 |
| Hippocampus, L | Efficiency | 0.081 ± 0.005 | 0.082 ± 0.004 | 14.31 | 0.003 |
| Thalamus, L | Efficiency | 0.068 ± 0.005 | 0.067 ± 0.003 | 9.12 | 0.018 |
ANCOVA analysis of covariance, FDR false discovery rate, HC healthy controls, SD standard deviation, MFG middle frontal gyrus, MTG middle temporal gyrus, IFG_Orb orbital inferior frontal gyrus, PCG posterior cingulate gyrus, STG superior temporal gyrus, STP superior temporal pole, L left, R right
*P-values that were corrected with FDR