Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 14;10:2672. doi: 10.1038/s41598-020-59354-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

T3, T4 and TSH after developmental exposure to PFHxS. (a) PFHxS decreased pup T3 levels at 25 mg/kg on PD 16/17, mean of the controls was 1.48 nM. Data shown as mean + SEM. n = 14–16 (except control with n = 18) litters represented by either a male or a female pup. (b) Pup T4 was reduced from 5 mg/kg PFHxS (absolute values previously reported³⁶. n = 14–16 (except control with n = 18) litters represented by either a male or a female pup. (c) TSH in male pups PD 16. n = 11–13. (d) T3 levels in dams on PD 22, mean of the controls was 1.45 nM. n = 13–15. (e) Dam serum T4 at PD 22 was reduced from 5 mg/kg PFHxS (absolute values previously reported³⁶). n = 13–15 (except control with n = 20). (f) Dam serum TSH at PD 22. n = 15–16. Data shown as mean + SEM. **p < 0.01 compared to control, ***p < 0.001 compared to control, ⁺⁺p < 0.01 for full model comparison of indicated dose of PFHxS compared to no PFHxS exposure in the control and EDmix group. ⁺⁺⁺p < 0.001 for full model comparison of indicated dose of PFHxS compared to no PFHxS exposure in the control and EDmix group. ED: EDmix. Px: PFHxS. PD: postnatal day. TSH: Thyroid stimulating hormone. T3: Tri-iodothyronine, N/A: not available.