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. 2020 Feb 14;10:2672. doi: 10.1038/s41598-020-59354-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Thyroid gland weight and histology PD 16/17 and 22 after developmental exposure to PFHxS. (a,b) Female pup thyroid gland weight at PD 17 and PD 22. Data shown as mean + SEM. n = 11–16. (d,e) Thyroid histopathology on male pup thyroid glands PD 16 and PD 22. Bars represent percentage of animals receiving indicated score. control n = 16–17 and 25-Px n = 13–14. (c,f) Representative images of thyroid tissue from a control male pup (c) receiving a score of A (no remarks) and a male pup from the 25-Px group (f) receiving a score of B (1 mild alteration, potentially within natural variation) for altered cellularity (arrowheads). * p < 0.05 compared to control, **p < 0.01 compared to control, ⁺p < 0.05 for full model comparison of indicated dose of PFHxS compared to no PFHxS exposure in the control and EDmix group. ⁺⁺p < 0.01 for full model comparison of indicated dose of PFHxS compared to no PFHxS exposure in the control and EDmix group. ED: EDmix. Px: PFHxS. PD: postnatal day.