Table 4.
Results from the two-way ANOVA (sex, genotype) on Positive and Negative Syndrome Scale (PANSS) and age of onset
| SNPs | Clinical variables | Females | Males | p | ||||
|---|---|---|---|---|---|---|---|---|
| G/G | G/C | C/C | G/G | G/C | C/C | |||
| rs539689 | PANSS-P | 22.6 ± 5.8 | 20.2 ± 5.4 | 19.3 ± 5.3 | 23.3 ± 6.2 | 20.4 ± 5.9 | 21.8 ± 5.6 | 0.097a/< 0.001b/0.428c |
| PANSS-N | 25.2 ± 5.9 | 24.3 ± 6.6 | 23.0 ± 5.7 | 25.9 ± 6.5 | 25.4 ± 6.4 | 23.8 ± 5.0 | 0.209a/0.086b/0.961c | |
| PANSS-G | 43.8 ± 8.2 | 41.2 ± 8.7 | 40.7 ± 6.3 | 46.8 ± 9.6 | 42.6 ± 8.9 | 42.1 ± 7.9 | 0.097a/< 0.01b/0.730c | |
| Total PANSS | 91.8 ± 17.1 | 85.7 ± 17.8 | 83.0 ± 13.2 | 96.0 ± 18.8 | 88.5 ± 17.0 | 87.7 ± 15.8 | < 0.05a/< 0.01b/0.907c | |
| Age of onset | 28.4 ± 8.2 | 27.4 ± 7.2 | 28.3 ± 7.1 | 23.4 ± 5.4 | 24.3 ± 5.9 | 25.3 ± 6.1 | < 0.001a/0.604b/0.394c | |
| A1/A1 | A1/A2 | A2/A2 | A1/A1 | A1/A2 | A2/A2 | |||
|---|---|---|---|---|---|---|---|---|
| rs9281590 | PANSS-P | 19.8 ± 6.1 | 21.9 ± 5.6 | 20.2 ± 5.4 | 21.0 ± 5.6 | 21.7 ± 6.0 | 22.0 ± 6.2 | 0.195a/0.299b/0.300c |
| PANSS-N | 22.5 ± 5.8 | 25.1 ± 6.3 | 24.2 ± 6.2 | 26.3 ± 6.4 | 24.9 ± 6.1 | 25.5 ± 6.4 | < 0.05a/0.828b/0.153c | |
| PANSS-G | 38.5 ± 6.1 | 43.5 ± 7.8 | 41.7 ± 8.8 | 45.9 ± 9.8 | 43.4 ± 8.6 | 44.5 ± 9.7 | < 0.01a/0.704b/< 0.05c | |
| Total PANSS | 80.8 ± 15.1 | 90.5 ± 16.9 | 86.2 ± 17.3 | 93.2 ± 18.8 | 90.1 ± 16.9 | 92.1 ± 18.7 | < 0.01a/0.520b/0.065c | |
| Age of onset | 26.1 ± 7.4 | 27.0 ± 8.1 | 29.4 ± 6.8 | 24.7 ± 6.1 | 23.8 ± 5.7 | 24.3 ± 5.8 | < 0.001a/0.101b/0.181c |
| C/C | C/T | T/T | C/C | C/T | T/T | |||
|---|---|---|---|---|---|---|---|---|
| rs2763979 | PANSS-P | 20.3 ± 5.4 | 21.6 ± 5.7 | 20.0 ± 6.1 | 22.0 ± 6.2 | 21.7 ± 6.0 | 21.0 ± 5.6 | 0.209a/0.468b/0.480c |
| PANSS-N | 24.3 ± 6.1 | 25.0 ± 6.3 | 22.5 ± 6.0 | 25.5 ± 6.4 | 24.9 ± 6.1 | 26.3 ± 6.4 | < 0.05a/0.864b/0.187c | |
| PANSS-G | 42.1 ± 8.7 | 42.9 ± 8.1 | 38.7 ± 6.2 | 44.5 ± 9.7 | 43.4 ± 8.6 | 45.9 ± 9.8 | < 0.01a/0.787b/0.089c | |
| Total PANSS | 86.8 ± 17.2 | 89.5 ± 17.2 | 81.2 ± 15.3 | 92.1 ± 18.7 | 90.1 ± 16.9 | 93.2 ± 18.8 | < 0.01a/0.680b/0.141c | |
| Age of onset | 29.2 ± 7.0 | 27.1 ± 7.9 | 26.4 ± 7.4 | 24.4 ± 5.8 | 23.7 ± 5.7 | 24.7 ± 6.1 | < 0.001a/0.144b/0.286c |
Values represent mean PANSS scores/mean age of onset (years) ± standard deviation
Nominally significant p values are given in bold
PANSS-P positive scale, PANSS-N negative scale, PANSS-G general psychopathology scale
aMain effect of sex
bMain effect of genotype
cSex × genotype interaction