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. 2020 Feb 14;11:885. doi: 10.1038/s41467-020-14728-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Interactions between α5N of Gα_i (salmon) and the receptor (blue) in the cavity at the cytoplasmic region of FPR2. b Comparison of the cytoplasmic regions of TM5 and TM6 and ICL3 in FPR2 (blue) and in μOR (PDB ID 6DDE), A1AR (PDB ID 6D9H), CB1 (PDB ID 6N4B) and rhodopsin (PDB ID 6CMO) (all dark gray). Gα_i in the structure of FPR2-G_i is shown in salmon. c Interactions between the ICL2 of FPR2 and Gα_i. d Interactions between FPR2 and Gβ.