Figure 1.

CCL2 deficiency reduces therapeutic efficacy of MSC in cutaneous wound healing. (a) Images of mouse excisional wounds between d-0 and d-10. Two 5 mm punch wounds were created on the dorsum of each mouse. (b) Left - Wound area was quantified at d-0 and no significant differences were observed between any of the groups (n ≥ 11, ns, not significant). (b) Right - Time course of wound closure from image analysis demonstrated accelerated wound closure in MSC-WT treated wounds (n ≥ 8, * = MSC-WT vs Control, ***p < 0.001). MSC-KO completely abrogated this therapeutic effect and were not statistically different to control treated wounds, but were statistically different to MSC-WT treated wounds at all time points (n ≥ 8, # = MSC-WT vs MSC-KO, #p < 0.05, ##p < 0.001).