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. 2020 Feb 14;10:2642. doi: 10.1038/s41598-020-59174-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MSC derived CCL2 is required for increased M2 polarisation of macrophages within the wound. (a) Representative images of wound sections d-10, stained for pan macrophage marker F4/80 (red) and M2 marker CD206 (green), cell nuclei were counter stained with DAPI (blue), for clarity arrowheads indicate CD206+ cells, scale bar 50 μm. (b) Left- total macrophage within the wound bed, no difference between any of the groups was detected at d-10 (n ≥ 8 ns, not significant). (b) Right- percentage macrophages co-expressing CD206 was significantly increased in MSC-WT treated wounds compared to both control and MSC-KO treated wounds. (n ≥ 8 ns, not significant ***p < 0.001).