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. 2020 Feb 14;10:2693. doi: 10.1038/s41598-020-59647-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Sting has limited impact on neuromuscular phenotypes. Locomotor assays analysing climbing ability (negative geotaxis) in (A) young and (B) older adult flies of control and Sting knockdown (RNAi) or null (Sting^ΔRG5) mutants. Charts show mean ± 95% confidence interval (CI); number of animals analysed is shown in each bar. Significance was measured by Kruskal-Wallis test with Dunn’s post hoc correction for multiple comparisons; **p < 0.01, ****p < 0.0001; ns, non-significant. Control genotype is da-GAL4/+. (C) Representative confocal microscopy analysis of mitochondria in flight muscles, immunostained with anti-ATP5A, in control (w¹¹¹⁸) and Sting heterozygous and homozygous mutants. Scale bar = 10 µm.