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. 2020 Feb 14;10:2693. doi: 10.1038/s41598-020-59647-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Sting does not ameliorate mtDNA mutator; parkin mutant combinations. Analysis of (A) locomotor (climbing) ability in young adults and (B) lifespan in flies combining mito-APOBEC1 mtDNA mutator expression with or without parkin and/or Sting. Transgene expression was driven by da-GAL4. Mito-GFP expression was used as a control. Charts show mean ± 95% confidence interval (CI); number of animals analysed is shown in each bar for climbing, and beside the genotype key for lifespan. For climbing, statistical significance was determined by Kruskal-Wallis test with Dunn’s post hoc correction for multiple comparisons; and for lifespan, by Log-rank (Mantel-Cox) test; **p < 0.01, ****p < 0.0001; ns, non-significant.