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. 2019 Nov 25;45(4):622–631. doi: 10.1038/s41386-019-0577-3

Fig. 2. Forest plot showing variability ratios (VR) and coefficient of variation ratios (CVR) for change in total symptoms in studies of clozapine relative to other antipsychotics for the treatment of patients with strictly-defined treatment-resistant schizophrenia (TRS) and other non-refractory schizophrenia (non-TRS).

Fig. 2

In studies of TRS, there is no significant alteration in the summary variability ratio (VR = 1.84, p = 0.124), indicating that the variability in response to treatment is the same in patients receiving clozapine as other antipsychotics. Furthermore, there is no significant alteration in the summary coefficient of variation ratio (CVR = 1.66, p = 0.220), indicating that the variability in response to treatment is the same in patients receiving clozapine as other antipsychotic drugs after adjusting for greater symptomatic improvement in the clozapine group. Similarly, the variability in response to treatment is the same in patients receiving clozapine relative to other antipsychotics in studies of non-TRS. CI, confidence interval; HAL, haloperidol; OLZ, olanzapine; RE, random effects; RIS, risperidone.