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. 2020 Feb 14;9(2):22. doi: 10.1038/s41389-020-0203-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a qRT-PCR analysis of uPAR mRNA expression in M14 cells transfected with mimic miR-378 and with siRNA against uPAR (si-uPAR) or the relative scramble control siRNA (si-Ctrl). The results are reported as fold ± SEM in cells transfected with si-uPAR respect to si-Ctrl. In vitro cell migration (b) and invasion (c) of M14 cells transiently transfected with mimic scramble miRNA control (mimic Ctrl), or mimic miR-378, or mimic miR-378 and siRNA oligonucleotides directed against uPAR (si-uPAR, 20 nM, 48 h), or M25 peptide (50 μM, 2 h) and relative scramble controls (si-Ctrl or peptide Ctrl, respectively). Values are expressed as fold of migrated/invaded cells respect to mimic Ctrl. d Evaluation of capillary-like structures formation in M14 cells transfected with mimic Ctrl, or mimic miR-378, or mimic miR-378 and si-uPAR or its relative control si-Ctrl. The fold of intersection points/field respect to mimic control was reported. a–d Data were expressed as average ± SD. Statistical analysis was performed applying t-test. *p < 0.05; ***p < 0.001.